Water used for reconstitution of an additive for a large volume parenteral should be:
Physicochemical factors affecting the rate and extent of percutaneous drug absorption include:
I the partition coefficient of the drug molecule
II the presence of surfactants in the formulation
III the type of ointment base
In an adequately powered, randomized controlled trial conducted over 3 years, a specific serious side effect (i.e. reduction in leukocytes) with conventional therapy is seen in 0.5% of the study sample. In patients who receive a newly discovered drug, only 0.45% experience the same side effect. Based on these results, the minimum number of patients that would have to receive the new drug for 3 years to statistically demonstrate the prevention of one episode of this side effect in at least one patient is:
In which of the following organs or tissues is the action of acetylcholine NOT described as "nicotinic"?
I Motor endplates of skeletal muscle
II Celiac ganglia
III Circular muscles of the iris
Bacterial resistance to an antibiotic may occurs due to:
I- Mutation
II- Adaptation
III- Gene transfer
Identify the correct pathway of blood flow from the small intestine to the liver:
The organophosphates commonly found in insecticides are thought to act by which of the following mechanisms?
Five subjects given a single intravenous dose of a drug have the following elimination half-lives: 3, 9, 6, 5 and 4 h (hours). The mean half-life is:
Correct administration of Penicillamine in the treatment of rheumatois arthritis include:
Organisms commonly implicated in the cause of Traveller's Diarrhea include:
I Bacteroides fragilis
II Escherichia coli
III Shigella sp
Which financial statement could be used to determine the total value of prescription drug sales for a pharmacy during the course of a year?
Which Cytochrome P450 isozyme does not participate appreciably in drug metabolism?
A patient purchasing sublingual nitroglycerin tablets should be told to store the medication:
Pannus is an inflammatory exudates characterized by:
I- Synovial cell proliferation inside of a joint
II- Normally occurs in patients with rheumatoid arthritis
III- An immunologic complication
For the majority of drugs, which of the following equations correctly defines clearance?
Cigarette smoke causes an increase in levels of CYP1A isozymes. Theophylline is primarily metabolized by the CYP1A system. What would happen to theophylline clearance for an asthmatic patient in hospital who could not smoke?
Approximately 50% of dicloxacillin is excreted unchanged in the urine. If the normal dosage schedule for dicloxacillin is 125 mg q6h, a patient with renal function 20% of normal should receive:
Viral encephalitis, a CNS infection, may be best be treated by which of the following agents?
Patient is resistant to chloroquine and need to be treated for malaria. Which of the following drugs or combination should be more appropriate for this patient?
Examples of very narrow spectrum penicillins include all of the following, EXCEPT:
Correct statements regarding Pellagra include:
I- Caused due to deficiency of niacin
II- Caused by failure in converting tryptophan to niacin
III- Characterized by dermatitis, diarrhea and dementia
Gonorrhea, a sexually transmitted disease may be treated by which of the following agents?
I- Cefixime
II- Ceftriaxone
III- Ciprofloxacin
Correct statements regarding CEPHALOSPORINS include:
I- Bactericidal antimicrobial
II- Derivated from natural source: Cephalosporium acremonium
III- Broad-spectrum agent
Diseases which are viral infections include:
I poliomyelitis
II rabies
III Legionnaires' disease
Nosocomial infections may be best treated by which of the following agents?
I- Cephalosporin 3rd generation
II- Macrolides antibiotics
III- Penicillins
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TESTED 20 May 2024
